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Boston scientists discover genetic variant that protects against Alzheimer’s disease symptoms

Published Sat, 22 Feb 2025 04:06:35 GMT

Researchers have made another breakthrough in their effort to help Alzheimer’s patients, as Boston scientists on Monday reported they have found a new genetic variant that protects against Alzheimer’s disease symptoms.Meanwhile, other researchers in the city recently discovered how the FDA-approved Alzheimer’s drug lecanemab slows cognitive decline, and the FDA gave the green light for a drug to treat agitation symptoms that are associated with dementia.Mass General Brigham investigators on Monday said they identified what’s causing Alzheimer’s, and also what protects against the disease — helping pave the way for future treatments.The researchers studied a patient with a genetic predisposition for early-onset Alzheimer’s disease who remained cognitively intact more than two decades beyond the expected age of memory impairment.“The genetic variant we have identified points to a pathway that can produce extreme resilience and protection against Alzheimer’s disease symptoms,” said Jos...

Olde Saratoga Coin, under new ownership, rebrands

Published Sat, 22 Feb 2025 04:06:35 GMT

ALBANY, N.Y. (NEWS10) -- Northeastern Fine Jewelry has purchased Olde Saratoga Coin and rebranded it as Olde Saratoga Coin & Jewelry. Olde Saratoga Coin & Jewelry has locations at 1593 Central Avenue in Colonie and 385 Broadway in Saratoga Springs. Get the latest, news, weather, sports and community events delivered right to your inbox! “Coins have always been one of my passions and how we got our start in business back in 1980,” said Ray Bleser, owner of Northeastern Fine Jewelry. “Our original store was Northeastern Coin Gallery in Schenectady. For me, returning to my roots is deeply nostalgic, intensely gratifying and truly exciting.”In 1985, Northeastern Coin Gallery was reincorporated as Northeastern Fine Jewelry. With locations in Albany, Schenectady, and Glens Falls, the store has world-renowned brands, diamonds, engagement rings, wedding bands, watches and estate items. Northeastern Fine Jewelry will continue to operate under its own name at those locations. Alba...

DEC: Injured angler rescued in Wilmington

Published Sat, 22 Feb 2025 04:06:35 GMT

WILMINGTON, N.Y. (NEWS10) -- On Saturday morning, Forest Rangers were notified about an angler with a possible broken leg off the Flume Trail System. Forest Rangers DiCintio, O'Connor, Praczkajlo, and Wilmington Fire and Wilmington EMS responded and located a 39-year-old from Canada. Get the latest, news, weather, sports and community events delivered right to your inbox! The angler told the rescue that his foot was trapped in the rapids and he had to injure himself to get out from under a rock. He then dragged himself from the water to the riverbank and waited for two hours before someone found him. The angler was placed onto a litter and carried to the ambulance.

Hyde Collection announced student art show winners

Published Sat, 22 Feb 2025 04:06:35 GMT

GLENS FALLS, N.Y. (NEWS10) - Earlier this month, the Hyde Collection welcomed its annual High School Juried Show. Now in its 32nd year, the show features art from school districts across five counties - some of whom took home awards. Get the latest, news, weather, sports and community events delivered right to your inbox! On Saturday, May 6, the art show's award winners were announced at the Helen Froehlich Auditorium at the museum. Jurors included Belinda Colón, Exhibitions Director at Spring Street Gallery; Rita McDonald, a regional professional artist; and Pearl Cafritz, Executive Director at Salem Art Works. The jurors evaluated 100 pieces of art, chosen from among 500 submissions in total.Awardees included:Best in Show"Sweet Work" by McKenna McWhorter, Argyle Central SchoolCurators Award"Off to the Show" by Sophia Verdu, Saratoga Springs High School"Brevis" and "Ollam Manubriis" by Lara Stanco, Lake George Senior High SchoolJurors Award"Eggs in a Carton" by Hailey Hamm, South...

St. Louis Circuit Attorney Kim Gardner resigning today

Published Sat, 22 Feb 2025 04:06:35 GMT

ST. LOUIS - Kim Gardner is stepping down as St. Louis Circuit Attorney two weeks ahead of schedule. Earlier this month, the embattled chief prosecutor announced she would resign effective June 1. Gardner, the city’s first African American chief prosecutor, will instead leave her post today, May 16.In a statement, Gardner said the St. Louis County Prosecuting Attorney's Office will handle priority cases until a replacement can be named.The Circuit Attorney has worked with St. Louis County Prosecuting Attorney Wesley Bell and his office to ensure a comprehensive transition plan is in place to handle cases that prioritizes public safety. Effective immediately, Kimberly M. Gardner will end her service as the City of St. Louis Circuit Attorney. Ms. Gardner has been committed to serving the people of the City of St. Louis and has done all she can to ensure a smooth transition. Further inquiries about ongoing cases can be directed to St. Louis County Prosecuting Attorney's OfficeStatement ...

Missouri rapper pleads guilty to illegal firearms

Published Sat, 22 Feb 2025 04:06:35 GMT

SPRINGFIELD, Mo. — A Springfield, Missouri, man has pleaded guilty to two counts of illegally possessing firearms, one of which was linked to several recent shootings. PREVIOUS COVERAGE: Springfield rappers arrested on illegal firearms charges According to a press release from the Department of Justice, Jardell Carlin Williams, 19, admitted he was in possession of a Glock .40-caliber semi-automatic pistol when a vehicle, in which he was a passenger, was stopped by the Springfield Police Department on Feb. 15, 2022.Williams also admitted he was in possession of a C3 Defense 5.56-caliber semi-automatic pistol when a vehicle, in which he was a passenger, was stopped by detectives with the Greene County Sheriff’s Department on Oct. 23, 2022.The press release states the AR-style pistol was identified as having been used in three shooting incidents in the Kansas City, Missouri, and Kansas City, Kansas, areas.Williams faces a sentence of up to 25 years in federal prison without parole. T...

New 14-story Clayton building features an acre of green space

Published Sat, 22 Feb 2025 04:06:35 GMT

CLAYTON, Mo. -- Construction of a new 14-story building called Forsyth Pointe in Clayton is now complete. Tenants, including Clayton based manufacturing technology supply company Barry-Wehmiller, will start moving in soon. The 226,000 square foot building is located at the intersection of Forsyth and Brentwood boulevards, across from Shaw Park. Busch Light brings ‘corn cans’ back to celebrate, support farmers There is currently 102,520 square feet of office space available for lease. The open floor plans feature column free design and 14-foot ceilings with glass curtain walls. The large lobby features a video wall plus 13,000 square feet of street-level retail and restaurant space.There is an acre of green space on the 7th floor. The garden terrace includes a fire pit, seating, and a fitness center. The building features five levels of covered parking and electric vehicle charging stations.

Grabowski’s Pizzeria closes in The Source after four years

Published Sat, 22 Feb 2025 04:06:35 GMT

Grabowski’s Pizzeria has checked out of The Source Hotel.Owner Jared Leonard closed the Chicago-style pizza shop, located at 3350 Brighton Blvd., on May 10 after he realized the space wasn’t the right fit for Grabowski’s anymore.“About 75 percent of our business was takeout, but for that space and rent, it really needs to be more of a cocktail bar or something where there’s more dine-in customers for the economics of it all to make sense,” Leonard said.Leonard, who also owns AJ’s Pit Bar-B-Q in Denver and Campfire in Evergreen and Lakewood, opened Grabowski’s in 2019. The owner of Chicago-based SSC Hospitality Group wanted to introduce Denver to the 1950s tavern-style pizzas with rectangular slices and a papery thin crust.And even though business was doing pretty well, Leonard said the vision for The Source has changed since Zeppelin Development sold The Source Hotel + Market Hall in RiNo to Los Angeles-based Stockdale Capital Partners for $70 million last year.He said parking...

Vivek Ramaswamy and His Wikipedia Problem

Published Sat, 22 Feb 2025 04:06:35 GMT

Your online presence can be a make-or-break factor for your personal brand, especially when you are involved in politics. Having a polished image in the digital world is now more important than ever.It is important that people keep up with their personal brand and ensure the accuracy of everything said about them online. But when it comes to editing your own Wikipedia page, how far is too far?Enter Vivek Ramaswamy, the entrepreneur and biotech investor whose recent actions have ignited heated discussions around the ethics of self-promotion. With him recently declaring his candidacy for the 2024 presidential election, it makes sense that he would want his online image to be as clean as possible.Ramaswamy and WikipediaRamaswamy recently made headlines for paying someone to edit his Wikipedia page. It was originally reported by Mediate before numerous other media outlets picked up on the story.The one change to his Wikipedia page that may be considered controversial include him being a...

ADL says Elon Musk’s attacks on George Soros ‘will embolden extremists’

Published Sat, 22 Feb 2025 04:06:35 GMT

By Chris Isidore | CNNNew York — Elon Musk launched a baseless Twitter attack on George Soros, a frequent target for antisemitic conspiracy theories, accusing the financier of hating humanity days after Soros disclosed having sold off a modest stake in Tesla.While Musk’s remarks don’t mention the billionaire philanthropist’s ethnicity, Musk was criticized for dangerous rhetoric that could potentially fuel further attacks on Soros.In a tweet late Monday, Musk compared him to X-Men villain Magneto, who like Soros was a survivor of the Holocaust, according to the comics’ back story for the character. When a Twitter user defended Soros as having good intentions which are criticized by those who disagree with his politics, Musk responded, “You assume they are good intentions. They are not. He wants to erode the very fabric of civilization. Soros hates humanity.”Jonathan Greenblatt, CEO of the Anti-Defamation League, a civil right group that tracks and battles incidents of antisemitism, c...